Warrington and Halton Hospitals

Rheumatology and Orthopaedic studies


Rheumatology

Dr Salih is the lead consultant for Rheumatology research with commercial and academic studies in Rheumatoid Arthritis, Ankylosing Spondylitis, Giant Cell Arteritis and Systemic Lupus Erythematosus.

Current studies include:

Sequence based genetic analysis of Systemic Lupus Erythematosus (SLE)

Using DNA from blood and clinical information, we can look at similarities and differences between people with SLE and those unaffected by the disease. These may help to identify genetic differences that are more common in SLE patients and then ask how these genetic factors affect the immune system and how they influence the nature and severity of the disease.

This study involves a one off consent, blood sample, patient questionnaire and data collection from patient notes that can be done as part of your out-patient clinic visit. 


UKGCA Consortium

Run by the University of Leeds, the purpose of the study is to find out more about the causes of giant cell arteritis (GCA, sometimes called temporal arteritis) and polymyalgia rheumatica (PMR).

We would also like to find out how to predict whether a person with one of these conditions will be more severely affected or only mildly affected.

The study involves a blood sample, patient questionnaire and data collection from hospital notes.

We hope that the findings of this research will help other patients with this condition in the future by leading to the development of better treatments for this disease, with fewer side-effects than the steroid treatment that is currently standard.

BSRBR-AS

The British Society for Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBR-AS) tracks the progress of a cohort of patients with axial spondyloarthritis who are taking biologic therapy, plus a comparison cohort of patients not on these drugs.

At regular time points, data will be collected by research nurses from patient notes and patients will complete postal questionnaires.

BSRBR-RA

The British Society for Rheumatology Biologics Register in Rheumatoid Arthritis (BSRBR-RA) tracks the progress of people with rheumatoid arthritis (RA) who have been prescribed biologic (including biosimilar) drugs in the UK to monitor the long-term safety of these drugs.

It is one of the largest prospective studies of patients receiving these drugs in the world with over 20,000 patients registered in the study since it started in 2001.

At regular time points, data will be collected by research nurses from patient notes and patients will complete postal questionnaires.

Find out more on their website here.

 


Further information

Please contact the research nurse on 01925 662946 if you would like any more information about research studies in Rheumatology.


Orthopaedics

Mr Stables is the principle investigator involved in national multicentre orthopaedic studies here at Warrington & Halton.

The specialities currently covered are:

  • Knee replacement
  • Wrist fractures

PATH-2 STUDY: Platelet Rich Plasma in Achilles Tendon Healing - A study looking at the best way to heal your torn Achilles tendon

The PATH-2 Study compares usual non-surgical plaster cast treatment for a torn Achilles tendon to a new treatment in which Platelet Rich Plasma (PRP) is injected into the torn tendon, in addition to receiving usual cast treatment. The aim is to see if PRP improves healing.

A new treatment has been developed, using an injection of ‘Platelet Rich Plasma’ (PRP). The aim of PRP is to improve the repair of the tendon. PRP aims to take advantage of the body’s normal healing abilities to help repair injuries. The cells in PRP contain special growth and regeneration factors that stimulate the body’s healing response in the injured tendon.

PRP is made using a sample of a person’s own blood. The blood sample is taken using a needle and syringe. The blood is spun in a machine called a centrifuge and after spinning what remains is the platelet rich plasma.

The person’s own PRP is then injected into their Achilles tendon at the site if the injury. A local anaesthetic is given at the tendon area before the PRP injection to help ease any discomfort.

The PRP injection is applied immediately prior to the cast, splint or boot.

PRP has been shown to accelerate healing in a small group of patients. A larger study (the PATH-2 Study), is now underway to look into this further to improve the evidence as to whether this is an effective treatment.

 


Further information

Please contact the research nurses on 01925 662946 if you would like any more information about research studies in Orthopaedics.


Consultant Led Research

Mr Pradhan, Orthopaedic Consultant, is running his own clinical trial into a new technique for performing knee replacements. Find out more by clicking here.

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